Hexadrol phosphate injection dexamethasone sodium phosphate is a corticosteroid used to treat a number of conditions including arthritis, bloodhormoneimmune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders, and certain cancers. Dexamethasone sodium phosphate drugspharmaceuticals with ndc code codes. Drugs az pill identifier supplements symptom checker diseases dictionary media. Dexamethasone sodium phosphate suppresses the inflammatory response to a variety of agents and it probably delays or slows healing. Chemical stability of dexamethasone sodium phosphate after. Dexamethasone sodium phosphate api dmfs us drug master.
Again, while both diseases are rare and far less common than the diseases dexamethasone sodium phosphate injections treat, this shortage can have detrimental effects. C is the concentration, in mg per ml, of usp dexamethasone phosphate rs in the standard preparation. Monograph for sodium phosphate world health organization. Influence of sodium chloride and dibasic sodium phosphate salt. Side effects of hexadrol dexamethasone sodium phosphate. The use of hexadrol phosphate injection dexamethasone sodium phosphate injection, usp in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculosis regimen. The mobile phase was a gradient of acetonitrile and 0. Pdf determination of dexamethasone and dexamethasone.
Dexamethasone sodium phosphate injection, usp 10 mgml. Immediately flush eyes with plenty of water for at least 15 to 20 minutes. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug. Search results for dexamethasone sodium phosphate at sigmaaldrich. Dexamethasone works by relieving symptoms such as swelling, redness, and itching. Dexamethasone sodium phosphate an overview sciencedirect.
Betamethasone sodium phosphate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. Dexamethasone sodium phosphate ophthalmic solution is used to treat eye inflammation caused by infections, injury, surgery, or other conditions. No generally accepted explanation of these steroid. Each ml of dexamethasone sodium phosphate injection, usp preservative free contains dexamethasone sodium phosphate, usp equivalent to 10 mg dexamethasone phosphate. Determination of dexamethasone sodium phosphate in the vitreous by high performance liquid chromatography. It has a role as a glucocorticoid receptor agonist. In adrenocortical insufficiency, it should be used together with a. Dexamethasone sodium phosphate is an organic sodium salt which is the disodium salt of dexamethasone phosphate. Dexamethasone sodium phosphate is a watersoluble inorganic ester of dexamethasone. Dexamethasone sodium phosphate drugspharmaceuticals with. Dexamethasone sodium phosphate definition of dexamethasone.
Widelydistributed,crossestheplacenta,andappearstoenterbreast milk. One such agent, the oral sodium phosphate solution fleet phosphosoda, c b fleet, lynchburg, has become increasingly popular as an alternative to gut. Mineralocorticoids, uniuqely aldosterone in human, regulate the balance of water and promote retention of sodium, loss of potassium. Sodium phosphate salt is rapidly absorbed after im administration. Trisodium phosphate tsp is the inorganic compound with the chemical formula na3po4. Dexamethasone sodium phosphate european pharmacopoeia 6. Route onset peak duration dexamethasone dexamethasone. Dexamethasone sodium phosphate injection is a sterile solution of dexamethasone sodium phosphate in water for injection. Trisodium phosphate, 2,3 diphosphoglycerate, oxygen uptake, off road cyclists. It belongs to a class of drugs known as corticosteroids. This medication is used to treat certain eye conditions due to inflammation or injury. A group mtdi of 70 mgkg bw, as phosphorus from all food sources, was established at the 26th jecfa 1982.
Material safety data sheet sodium phosphate, dibasic. This is a pdf file of an unedited manuscript that has been. If the suffix psy, narc or drug precursor, or motbiotox appears, export authorizations are mandatory in france or. Dexamethasone sodium phosphate injection, usp 10 mgml drug. When given intramuscularly, dexamethasone sodium phosphate is absorbed much faster from the injection site than dexamethasone acetate. Dexamethasone sodium phosphate powder usp fagron, inc.
Dexamethasone is a synthetic analog of naturally occurring glucocorticoids hydrocortisone and cortisone. Hexadrol phosphate injection is also used as a test for an adrenal gland disorder. Dexamethasone sodium phosphate injection, usp 10 mgml dexamethasone sodium phosphate install pdr s official, free drug information and comparison app today. Sep 01, 2019 dexamethasone sodium phosphate injection usp is a sterile, clear, colorless solution, free from visible particles and a watersoluble inorganic ester of dexamethasone which produces a rapid response even when injected intramuscularly. Find patient medical information for dexamethasone sodium phosphate pf injection on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Dexamethasone sodium phosphate injection, 10 mgml for intravenous and intramuscular injection only. Dexamethasone sodium phosphate is an adrenocortical steroid antiinflammatory drug.
Dexamethasone sodium phosphate ophthalmic solution is in a class called corticosteroids. Trisodium orthophosphate, trisodium phosphate, trisodium. Dexamethasone sodium phosphate usp, c22h28fna2o8p, has a molecular weight of 516. Favorites subscribe to favorite the drugs you use most often for quick access. Compatibility and stability of dexamethasone sodium. Dexamethasone sodium phosphate injection, usp 4 mgml is a sterile solution for intravenous, intramuscular, intraarticular, intralesional and soft tissue administration. Dexamethasone sodium phosphate ophthalmic solution pet. Effects of sodium phosphate loading on aerobic power and. Berzelius himself in dicated the nature of the reaction between disodium phosphate and carbonic acid, which we. Spironolactone is the aldosterone antagonist called potassiumsparing diuretic used in the treatment of hypertension. Pdf determination of dexamethasone and dexamethasone sodium. Breathing sodium phosphate dibasic can irritate the nose and throat causing coughing and wheezing.
Subscribe to plumbs veterinary drugs to create and save personal notes for every drug you use. Suspensions of dexamethasone sodium phosphate 4 mgml injection solution in a 1. Dexamethasone is a type of corticosteroid medication. Jun 21, 2017 hexadrol phosphate injection dexamethasone sodium phosphate is a corticosteroid used to treat a number of conditions including arthritis, bloodhormoneimmune system disorders, allergic reactions, certain skin and eye conditions, breathing problems, certain bowel disorders, and certain cancers. Determination of dexamethasone sodium phosphate in the. It is used to inhibit inflammation and, therefore, swelling and pain from inflammation is lessened. Hexadrol phosphate injection dexamethasone sodium phosphate.
Dexamethasone sodium phosphate injection, usp is a sterile solution of dexamethasone sodium phosphate, and is supplied in 4 mg ml and 10 mg ml. Absorption from localsites intraarticular,intralesionalisslowbutcomplete. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. Manufacturers of dexamethasone sodium phosphate that have been granted an ndc national drug code. Considering the lower concentration of dexamethasone sodium phosphate in the combination, the wavelength of 242 nm was chosen for the analysis.
Dexamethasone sodium phosphate drug information chemocare. Reduces inflammation by suppressing polymorphonuclear leukocyte migration, reversing increased capillary permeability, and stabilizing leukocyte lysosomal membranes. A rapid, simple and sensitive liquid chromatographytandem mass spectrometry lcmsms assay was developed for the determination of dexamethasone dex and dexamethasone sodium phosphate dex sp. C is the concentration,in mg per ml,of usp dexamethasone phosphate rs in the standard preparation. Jun 21, 2017 the use of hexadrol phosphate injection dexamethasone sodium phosphate injection, usp in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculosis regimen. Dexamethasone sodium phosphate powder usp about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. It occurs as a white or slightly yellow crystalline powder, is odorless or has a slight odor of alcohol, is exceedingly hygroscopic and is freely soluble in water. Dsp is a white or slightly yellow crystalline powder which is particularly suitable for intravenous administration because it is highly water soluble. Dexamethasone sodium phosphate c22h28fna2o8p pubchem. Calcium chloride injections are vital to both hypocalcemic tetany, since the cause of the illness is a lack of calcium, and recoveries from open heart surgeries.
Dexamethasone sodium phosphate injection has immunosuppressive doses of corticosteroids. The chromophores of the analytes are quite different. Dailymed dexamethasone sodium phosphate injection, solution. List of drug master files dmf of dexamethasone sodium phosphate active pharmaceutical ingredient api submitted to the u. Dexamethasone sodiumphosphate fda prescribing information. Dexamethasone is a corticosteroid hormone glucocorticoid. Jun 08, 2018 dexamethasone sodium phosphate is a watersoluble inorganic ester of dexamethasone. Pdf injectable dexamethasone sodium phosphate administered. Sodium phosphates iv dosing, indications, interactions.
Structure, properties, spectra, suppliers and links for. Dexamethasone sodium phosphate should be administered at a rate of 24mgkg i. This injectable form of dexamethasone is used when a similar drug cannot be taken by mouth or when a very fast response is needed, especially in patients with severe medical conditions. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper. Dexamethasone sodium phosphate c22h28fna2o8p chemspider. Dexamethasone sodium phosphate injection can be given directly from the vial, or it can be added to sodium chloride injection or dextrose injection and administered by intravenous drip. Dexamethasone sodium phosphate, powder, usp is corticosteroid that has strong antiinflammatory and immunosuppressant effects. Dexamethasone sodium phosphate injection usp is a sterile, clear, colorless solution, free from visible particles and a watersoluble inorganic ester of dexamethasone which produces a rapid response even when injected intramuscularly. Dexamethasone sodium phosphate decadron, dexasone, diodex, hexadrol, maxidex glucocorticosteroid, how its given, how it works, precautions and self care tips for treatment of side effects from chemotherapy treatment. Find patient medical information for dexamethasone sodium phosphate ophthalmic on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. A life threatening complication after ingestion of sodium phosphate. Dexamethasone sodium phosphate, chemical structure. Hexadrol dexamethasone sodium phosphate injection, usp.
If an immediate effect is required, dexamethasone sodium phosphate should be administered intravenously because it has a more rapid effect than the same preparation given intramuscularly. Dexamethasone sodium phosphate solution for injection 4 mgml may be administered into joints, soft tissues, or lesions, but administration of dexamethasone via these routes requires specialized techniques. Sigmaaldrich offers a number of dexamethasone sodium phosphate products. Dexamethasone sodium phosphate dsp is a salt of dexamethasone, a synthetic corticosteroid which possesses glucocorticoid activity. This was an open label, crossover study of 11 healthy. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic. All spectrum chemical usp products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Dexamethasone sodium phosphate injection, mm thromboembolism 9. Shock unresponsive to conventional therapy 11,17dihydroxy16methyl21phosphonooxy, 1. For advice, contact a poisons information centre or a doctor.
The chemical stability of dexamethasone sodium phosphate 1 mgml and 0. Calculate concomitant amount of sodium that will be administered. Aldosterone plays a role also in promoting tissue repair. The influence of sodium chloride nacl and dibasic sodium phosphate na2hpo42h2o, dsp on the phase transformation and particle size. Compatibility and stability of dexamethasone sodium phosphate. Antiinflammatory pregnancy risk category c action unclear. Dexamethasone sodium phosphate solution for injection 4 mgml or 10 mgml may be added to 5% dextrose injection or 0.
A rapid, simple and sensitive liquid chromatographytandem mass spectrometry lcmsms assay was developed for the determination of dexamethasone dex. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, ocular pain following ophthalmic surgery, and along with antibiotics in tuberculosis. Dexamethasone sodium phosphate aka dexamethasone sodium phosphate is a human prescription drug product labeled by pfizer laboratories div pfizer inc. Dexamethasone sodium phosphate fda prescribing information. The type iii sodiumdependent phosphate transporters, pit1 and pit2. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Dexamethasone sodium phosphate, powder, usp 2392394. Dexamethasone sodium phosphate is a water soluble, inorganic ester of dexamethasone.
Talk to your doctor about the risks and benefits of dexamethasone. Material may be irritating to the mucous membranes and upper respiratory tract. Nonhazardous ingredients include water for injection and sodium citrate. Betamethasone sodium phosphate msds special notice. The concentrations of the drug were directly related to peak heights, and the percent. Material safety data sheet sodium phosphate, dibasic, anhydrous, acs 2 section 4 first aid measures eyes.
525 385 1481 554 545 1475 36 232 452 1354 1199 618 571 7 443 1194 1410 552 1156 1461 70 707 1457 727 745 76 803 1246 687 1324 753 1054